Brongevity: Longevity, Wellness, Personal Development, Habits & Human Performance

How Mitochondrial Dysfunction Accelerates Aging

Bronson Wilks Episode 143

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Aging isn’t just about time passing — it’s about energy loss at the cellular level.

In this episode, we break down how mitochondrial dysfunction accelerates aging and why declining cellular energy production is one of the primary drivers of fatigue, brain fog, metabolic disease, inflammation, and age-related decline.

You’ll learn how mitochondria regulate far more than ATP — including oxidative stress, apoptosis, immune signaling, and metabolic flexibility — and why damage to mitochondrial DNA creates a self-reinforcing cycle that speeds up biological aging.

We explore:

  • The mitochondrial theory of aging
  • Why mitochondrial DNA is uniquely vulnerable to damage
  • How dysfunctional mitochondria drive cellular senescence and chronic inflammation
  • Why aging feels like an energy crisis, not just “getting older”

If you want to understand aging at its root — and why protecting mitochondrial health is foundational to longevity — this episode lays the scientific groundwork.

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